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KMID : 1030220160170010060
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Journal of Korean Diabetes
2016 Volume.17 No. 1 p.60 ~ p.66
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A Case of Autoantibody-Positive Ketosis-Prone Diabetes Mellitus
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윤보라:Yoon Bo-Ra
김규리:Kim Gyu-Ri/배재현:Bae Jae-Hyun/윤유정:Yun Yu-Jung/이용호:Lee Yong-Ho/이병완:Lee Byung-Wan/안철우:Ahn Chul-Woo/차봉수:Cha Bong-Soo/이현철:Lee Hyun-Chul/강은석:Kang Eun-Seok
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Abstract
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Ketosis-prone diabetes mellitus (KPD), which is an atypical type of diabetic mellitus with severe β cell dysfunction, is accompanied by ketosis or ketoacidosis without specific preceding factors at diagnosis. KPD shows mixed features of type 1 and type 2 diabetes. In some cases, the recovery of the function of β cells during intensified diabetic management enabled the termination of insulin therapy. The Aβ classification system classifies KPD patients into four distinct subgroups depending upon the presence or absence of β cell autoimmunity and β cell functional reserve and has been recognized as an important tool to predict clinical outcomes. In Korea, several cases of KPD with absence of β cell autoimmunity have been reported. A 60-yearold man presenting with DKA (diabetic ketoacidosis) as the first manifestation of diabetes, was shown to have β cell autoimmunity. A significant improvement in glycemic control was shown as a result of aggressive diabetic management; shortly after an acute episode of DKA, the recovery of β cell functional reserve was confirmed. This result allowed discontinuation of insulin therapy and maintenance of euglycemic status without antidiabetic medication.
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KEYWORD
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Diabetic ketoacidosis, Type 2 diabetes mellitus
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